简介
吴钟凯，男，一级主任医师，二级教授，研究员，心血管医学部副主任，心脏外科主任，博士导师，博士学历，毕业于1988年。一直在临床一线工作的心脏外科医生，临床经验丰富。每年主刀手术150-300例，临床医疗效果达到国内先进水平。医德医风优良，从医三十年来，无投诉和医疗纠纷。医疗专长熟悉先天性心脏病、心脏瓣膜病和冠心病外科手术治疗及术前后诊治处理。围术期器官保护专家。擅长冠脉搭桥术包括不停跳冠脉搭桥术手术。在冠心病高发区芬兰从事心脏外科临床工作和临床研究4年，有近千例冠脉搭桥手术主刀及一助经验。对心脏术中心肌保护有较深的造诣和一定的国际影响。保留瓣下结构二尖瓣置换术对提高重症二尖瓣病变的治疗效果，瓣膜整形和心房纤颤的外科治疗有深入的研究。近年来致力于儿童心脏移植，最小年龄3岁心脏移植后一直健康成长近4年。创立‘爱济童心’慈善基金，资助贫困地区和贫困家庭的先心病患者手术。是国家杰出青年科学基金获得者、“新世纪百千万人才工程”国家级人才、第十一届广州十大杰出青年、享受国务院特殊津贴专家、广东省高等学校珠江学者特聘教授、首届中山大学名医。主要研究方向心脏手术术中心肌保护；复杂先心病；不停跳冠脉搭桥手术；小儿心脏移植。社会兼职广东省政协委员中华医学会心胸血管外科分会委员中国先心病专家委员会委员卫生部辅助循环重点实验室副主任，心血管医学部副主任。第十二届、第十三届国家自然基金委专家评审专家成员（二审专家）。《中华胸心血管外科杂志》第六届编辑委员会编辑委员专业杂志Chinese Journal of Clinical Medicine （Engl）编委。专业杂志中华临床医师杂志（电子版）Chinese Journal of Clinicians常务编委。新医学编委。岭南心血管杂志编委。membership in the Scandinavian Society for Research in Cardiothoracic Surgery专业杂志《Circulation》、《The Annals of Thoracic Surgery》、《The American Journal of Cardiology》、《Chest》和《Chinese Medical Journal》审稿人。中国医师协会心血管外科医师分会学术委员会委员广东省医师协会心血管外科医师分会副主任委员。广东省心胸外科协会副主任委员。广州市青年联合会常务委员。获奖情况2002年芬兰心胸外科特别奖，2003年北欧心胸外科协会Karl Victor Hall Award。2005年国家杰出青年科学基金获得者。2006年“新世纪百千万人才工程”国家级人才。2006年广东省千百十工程省级培养对象。2010年第十一届广州十大杰出青年2010年获国务院特殊津贴专家2010年广东省千百十工程先进个人2011年广东省珠江学者特聘教授2011年北欧心胸外科协会Karl Victor Hall Award。论著共发表论文74篇，其中SCI 杂志发表第一作者和通讯作者论文36篇。在SCI 杂志发表的第一作者和通讯作者论文：1. Simvastatin attenuates pulmonary vascular remodeling by down-regulating matrix metalloproteinases-1,9 expressions in carotid artery-jugular vein shunt pulmonary hypertension model of rats. Eur. J. Cardiothorac. Surg 2012; (通讯作者).2. Controlled Oxygen Reperfusion Protects the Lung against Early Ischemia- Reperfusion Injury in Cardiopulmonary Bypasses by Down-regulating High Mobility Group Box 1 Experimental Lung Research 2012（通讯作者).3. Mai Xiong, Zhong-Kai Wu. Fibrosis of pulmonary vascular remodeling in carotid artery-jugular vein shunt pulmonary artery hypertension model of rats. Eur. J. Cardiothorac. Surg 2012; 41(1): p. 162-166 (通讯作者).4. Gao X, Peng L, Zeng Q, Wu ZK. Relationship between autonomic nervous function and arrhythmias in patients with acute viral myocarditis. Cardiology. ,2009,113(1):66-71. (通讯作者).5. Wu ZK, Laurikka J, Vikman S, Nieminen R, Moilanen E, Tarkka MR. High Postoperative Interleukin-8 Levels Related to Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery.World J Surg. 2008 Dec;32(12):2643-9. (通讯作者).6. Xu YQ, Wu ZK. Successfully surgical correction of total anomalous systemic venous drainage: two cases report. Heart Surgery Forum 2007;10(5):E415-7 (通讯作者).7. ZK Wu, S Vikman, J Laurikka, E Pehkonen, T Iivainen, HV Huikuri, and MR Tarkka. Nonlinear heart rate variability in CABG patients and the preconditioning effect. Eur. J. Cardiothorac. Surg 2005; 28: 109-13. (通讯作者).8. Zhang X, Wu ZK, Yao JP, et al. Aortopulmonary window—a case diagnosed by UFCT and the corrected method after transaortic patch closure with aortic narrowing. Chinese Medical Journal 2004;117：1750-1752。(通讯作者)9. Wu ZK, Iivainen T, Pehkonen E, et al. The antiarrhythmic effect of ischemic preconditioning in recent unstable angina patients undergoing coronary artery bypass grafting. World J Surg. 2004;28:74-9.10. Wu ZK, Iivainen T, Pehkonen E, et al. Recent unstable angina and off-pump coronary artery bypass grafting is not related to postoperative atrial fibrillation。Scand Cardiovasc J. 2003;37:334-9.11. Wu ZK, Iivainen T, Pehkonen E, et al. Fibrillation in patients subjected to coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;126:1477-82.12. Wu ZK, Iivainen T, Pehkonen E, et al. Arrhythmias in off-pump coronary artery bypass grafting patients and the antiarrhythmic effect of regional ischemic preconditioning. J Cardiothorac Vasc Anesth 2003;17:459-64.13. Wu ZK, Laurikka J, Saraste A, et al. Cardiomyocyte apoptosis and ischemic preconditioning in open heart operations. Ann Thorac Surg 2003;76:528-534.14. Wu ZK, Iivainen T, Pehkonen E, et al. Perioperaive and postoperative arrhythmia in 3-vessel coronary artery disease patients and antiarrhythmic effects of ischemic preconditioning. European J of Cardio-thoracic Surg 2003;23: 578-584.15. Tarkka MR, Wu ZK. Ischemic preconditioning in cardiac surgery. Int J Angiology 2003;12:34-47. (通讯作者)16. Wu ZK, Iivainen T, Pehkonen E, et al. Ischemic preconditioning suppresses ventricular tachyarrhythmias after myocardial revascularization Circulation. 2002;106:3091-3096.17. Wu ZK, Pehkonen E, Laurikka J, et al. Ischemic preconditioning protects right ventricular function in coronary artery bypass grafting patients experiencing angina within 48-72 hours. J Cardiovasc Surg 2002;43:319-26.18. Wu ZK, Pehkonen E, Laurikka J, et al. The protective effects of preconditioning decline in aged patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2001;122:972-8.19. Wu ZK, Pehkonen E, Laurikka J, et al. Preceding unstable angina affects inflammatory response and haemodynamics after coronary artery bypass surgery. International J of Angiology 2001;10:80-84.20. Wu ZK, Pehkonen E, Laurikka J, et al. Myocardial lactate production is not involved in the ischaemic preconditioning mechanism in CABG patients. J Cardiothorac Vasc Anesth. 2001;15:412-7.21. Wu ZK, Tarkka MR, Eloranta J, et al. Effect of ischaemic preconditioning, cardiopulmonary bypass and myocardial ischaemic/reperfusion on free radicals generation in CABG patients. Cardiovasc Surg. 2001;9:362-8.22. Wu ZK, Tarkka MR, Eloranta J, et al. Effect of ischemic preconditioning (IP) on myocardial protection in CABG patients: Can the free radicals act as a trigger for IP? Chest 2000; 119:1061-8.23. Wu ZK, Pehkonen E, Laurikka J, et al. Protective effect of unstable angina in coronary artery bypass surgery. Scand Cardiovasc J 2000;34: 486-492.24. Wu ZK, Tarkka MR, Pehkonen E, et al. Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting. Ann Thorac Surg. 2000;70:1551-7.25. Wu ZK, Sun PW, Zhang X, et al. Superiority of Mitral Valve Replacement with Preservation of Subvalvular Structure to Conventional Replacement in Severe Rheumatic Mitral Valve Disease. J Heart Valve Dis 2000;9:616-622.26. Wu ZK, Tarkka MR, Pehkonen E, et al. Ischaemic Preconditioning has a Beneficial Effect on Left Ventricular HeamodynamicSCI 杂志发表的第二作者等论文：27. Liu Z, Vuohelainen V, Tarkka M, Tenhunen J, Lappalainen RS, Narkilahti S, Paavonen T, Oksala N, Wu Z, Mennander A. Glutamate release predicts ongoing myocardial ischemia of rat hearts Scand J Clin Lab Invest. 2010;70:217-24.28. Huang SH, Gu LJ, Rong JIAN, Wu ZK. Dynamics of interstitial calcium in rat myocardial ischemia reperfusion injury in vivo. EUROPEAN HEART JOURNAL SUPPLEMENTS 2010，12：F18. (摘要，通讯作者)29. Zhang X, Xiong M, Wang ZP, Yin SL, Wu ZK, Xu YQ, Tang BY, Yao JP, Chen GX. Heart-lung transplantation for end-stage heart disease with Eisenmengers syndrome: report of two cases. Chin Med J (Engl). 2009;122:2189-92.30. Huang G, Wang A, Li X, Long M, Du Z, Hu C, Luo C, Wu Z, Tang L.Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation. J Hypertens. 2009;27:1829-1837.31. Huang G, Luo C, Gu X, Wu Z, Wang Z, Du Z, Hu C, Tang L.Mechanical strain induces expression of C-reactive protein in human blood vessels. J Pharmacol Exp Ther. 2009;330:206-11.32. He J, Chen Y, Huang Y, Yao F, Wu ZK, Chen S, Wang L, Xiao P, Dai G, Meng R, Zhang C, Tang L, Huang Y, Li Z. Effect of long-term B-type natriuretic peptide treatment on left ventricular remodeling and function after myocardial infarction in rats. Eur J Pharmacol. 2009;602:132-7.33. Czibik G, Wu Z, Berne GP, Tarkka M, Vaage J, Laurikka J, J?rvinen O, Valen G.Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart. Eur J Cardiothorac Surg. 2008;34:976-84.31. Liu WB, Xia Q, Men LN, Wu ZK, Huang RX. Dysphonia as a primary manifestation in myasthenia gravis (MG): a retrospective review of 7 cases among 1520 MG patients. J Neurol Sci. 2007;260(1-2):16-22..32. X Zhang, Z Xu, YQ Xu, ZP Wang, ZK Wu, BY Tang, M Xiong, JP Yao, PW Sun, and FT Zhong. Surgical intervention for advanced valvular heart disease in 227 cases. Chin Med J (Engl) 2005; 118: 989-94.33. Czibik, G, Wu ZK, Berne GP, et al. Hypoxia-inducible factor 1 alpha is not activated by human heart preconditioning. J Mol Cell Cardiol 2004;36:723.34. Laurikka J, Wu ZK, Iisalo P, et al. Ischemic preconditioning improves myocardial performance in off-pump coronary artery bypass grafting. Chest 2002;121:1183-9.35. Tarkka MR, Wu ZK. Ischaemic Preconditioning in CPB Surgery. Scand Cardiovase J . 2000;34: 231-232.在中文杂志发表的论文：1 刘子由,吴钟凯,陈光献,刘海. 大鼠心肌肥厚模型中血清白细胞介素-18及-10的变化. 中山大学学报·医学科学版 2009,30(3):280-2832 陈光献,唐白云,张金涛,吴钟凯. 心脏手术合并肺静脉高压术后近期疗效分析. 中华全科医学 2009,7(5):447-4493 Guang-Xian Chen,Meng-Ya Liang,Hai Liu,Zhong-Kai Wu,et al. Tetralogy of Fallot with Absent Pulmonary Valve and Pulmonary Artery Aneurysm: A Case Report of Surgical Cure.South China Journal of Cardiology.2009,10(2):94-964 陈光献,张金涛,唐白云,吴钟凯. 先天性心脏病合并肺动脉高压术后近期疗效分析. 中华全科医学 2009,7(8):791-7935 陈光献,唐白云,梁孟亚,刘海,吴钟凯. 远程预处理通过下调钙网蛋白高表达减轻在体大鼠心肌细胞缺血再灌注损伤. 中国病理生理杂志 2009,25(8):1469-14736 陈光献,梁孟亚,唐白云,张金涛,吴钟凯,张希. 肺动脉高压心脏手术后危象多因素分析. 中华全科医学 2009,7(9):909-9117 陈光献,唐白云,张希,熊迈,吴钟凯. 体外循环术后腹部并发症的防治. 中华胃肠外科杂志.2009,12(5):526-527
