简介
研究方向为结直肠肿瘤发生发展分子机制研究，主要研究内容为遗传多态性与肠癌易感性。开展MAPK信号通路关键基因多态性与结直肠肿瘤发病相关的课题，研究发现c-Jun、NfkBIa、MKK4、MEK5等多个基因多态性与肠癌易感性相关。近年来围绕非编码RNA在结直肠肿瘤发生发展中的作用开展相关研究。此外，在表观遗传、肠癌侵袭转移方面也进行深入研究。研究结果在 Carcinogenesis，International Journal of oncology, PloS One，International Journal of Clinical Practice，Proteomics Clinical Applications， DNA and Cell Biology，British Journal of Cancer， Journal of Gastrointestinal Surgery， Human Pathology等杂志上发表目前为止，作为主要作者发表文章多篇，其中SCI文章14篇，其中通讯/第一作者4篇。曾获中山大学优秀研究生导师逸仙创新人才培养计划、教育部博士研究生学术新人奖资助，主持承担国家自然科学基金青年项目、广东省自然科学基金面上项目、中山大学青年教师培育项目3项，参与多项国家自然科学基金、教育部博士点基金、广东省自然科学基金等项目研究。教育经历：2007/9 - 2012/6，中山大学，医学博士2002/9 - 2007/7，中山大学，医学学士工作经历：2016/01-至今，中山大学附属第六医院，主治医师2012/07-2015/12，中山大学附属第六医院，医师2012/07-至今，中山大学，附属第六医院，讲师近年发表相关论文:1.第一作者论文(1) Chen D#, Song S, Lu J, Luo Y, Yang Z, Huang Q, Fu X, Fan X, Wei Y, Wang J*, Wang L*. Functional variants of -1318T > G and -673C > T in c-Jun promoter region associated with increased colorectal cancer risk by elevating promoter activity. Carcinogenesis. 2011; 32:1043-9(2) Song S#, Chen D#, Lu J, Liao J, Luo Y, Yang Z, Fu X, Fan X, Wei Y, Yang L, Wang L*, Wang J*. NFkappaB1 and NFkappaBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population. PLoS One 2011; 6:e217262.通讯作者论文(1) Zixu Yuan#, Xihu Yu, Beibei Ni, Daici Chen, Zihuan Yang, Jintuan Huang, Jianping Wang, Dianke Chen*, Lei Wang* .Overexpression of novel long noncoding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/β-catenin signaling and predicts favorable prognosis. International journal of oncology. 2016 ;48(6):2675-85(2) Ni B#, Yu X, Guo X, Fan X, Yang Z, Wu P, Yuan Z, Deng Y, Wang J, Chen D*，Wang L*.Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. International journal of oncology. 2015; 47: 1329-383.既非第一作者又非通讯作者论文(1) Deng Y*, Wang L, Tan S, Kim GP, Dou R, Chen D, Cai Y, Fu X, Wang L, Zhu J, Wang J*.KRAS as a predictor of poor prognosis and benefit from postoperative FOLFOX chemotherapy in patients with stage II and III colorectal cancer. Molecular Oncology. 2015; 9(7):1341-7(2) Song S#, Chen D, Ma T, Luo Y, Yang Z, Wang D, Fan X, Qin Q, Ni B, Guo X, Xian Z, Lan P, Cao X, Li M, Wang J*, Wang L*. Molecular mechanism of acute radiation enteritis revealed using proteomics and biological signaling network analysis in rats. Digestive Diseases and Sciences. 2014, 59(11):2704-13.(3) Huang Q#, Chen D, Song S, Fu X, Wei Y, Lu J, Wang L*, Wang J*. A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer. Oncology Letters. 2013 Jul; 6(1):3-8(4) Fan XJ#, Wan XB#, Yang ZL#, Fu XH, Huang Y, Chen DK, Song SX, Liu Q, Xiao HY, Wang L*, Wang JP* Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial mesenchymal transition in colorectal cancer. Human Pathology 2013；44(2):173-80(5) Diao D#, Wang L, Zhang J, Chen D ,Liu H, Wei Y, Lu j, Peng J*, Wang J*. Mitogen/Extracellular Signal-Regulated Kinase Kinase-5 Promoter Region Polymorphisms Affect the Risk of Sporadic Colorectal Cancer in a Southern Chinese Population. DNA and Cell Biology.2012; 31(3):342-9(6) Fan XJ#, Wan XB#, Huang Y#, Cai HM, Fu XH, Yang ZL, Chen DK, Song SX, Wu PH, Liu Q, Wang L*, Wang JP*. Epithelial-mesenchymal transition biomarkers and support vector machine guided model in preoperatively predicting regional lymph node metastasis for rectal cancer. British Journal of Cancer. 2012; 106(11):1735-41(7) Luo Y#, Chen D, Song S, Wang L*, Wang J*.Aberrant methylation of genes in stool samples as diagnostic biomarkers for colorectal cancer or adenomas: A meta-analysis. International Journal of Clinical Practice.2011; 65:1313-20(8) Liu B#, Chen D, Yang L, Li Y, Ling X, Liu L, Ji W, Wei Y, Wang J, Wei Q, Wang L*, Lu J*. A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. Carcinogenesis. 2010; 31:1405-11(9) Luo Y#, Wang L#, Chen C#, Chen D, Huang M, Huang Y, Peng J, Lan P, Cui J, Cai S, Wang J*. Simultaneous liver and colorectal resections are safe for synchronous colorectal liver metastases. Journal of Gastrointestinal Surgery. 2010; 14:1974-80.(10) Luo YX#, Cui J, Wang L, Chen DK, Peng JS, Lan P, Huang MJ, Huang YH, Cai SR, Hu KH, Li MT, Wang JP*. Identification of cancer-associated proteins by proteomics and downregulation of beta-tropomyosin expression in colorectal adenoma and cancer. Proteomics Clinical Applications .2009; 3:1397-406.4.中文文章(1)王磊,陈典克,汪建平. 结直肠癌分子分型研究发展方向. 中华实验外科杂志. 2012, 29(2):176-7(2)王磊, 陈典克, 汪建平. 重视结直肠癌的预防与筛查. 中华实验外科杂志. 2011, 28(1):9-11(3)赵日升, 王辉, 王磊, 黄美近, 陈典克, 汪建平. 术前腔内支架与急诊手术治疗左半结肠和直肠癌肠梗阻的安全性与有效性Meta分析. 中华胃肠外科杂志,2012,15(7):697-701(4)鲜振宇,王磊,任东林,陈典克,宋顺心,黄清华,汪建平,刁德昌. ERK5基因 -322G/T多态性与散发性结直肠癌易感性的关系. 中国病理生理杂志. 2011,27(4):699-704(5)王磊, 杨祖立, 陈典克, 宋顺心, 兰平, 汪建平. MKK4腺病毒载体的构建及其对胰腺癌细胞增生和浸润能力的影响. 中华实验外科杂志. 2010,27(9): 1283-1285(6)傅新晖, 邓艳红, 范新娟, 骆衍新, 陈典克，王磊, 兰平, 刘焕亮, 汪建平. 利用高分辨率熔解曲线分析法检测结直肠癌中KRAS基因突变. 中华普通外科学文献(电子版). 2009, 3(5): 376-378.
