简介
张宁：主任医师，教授，博士生导师。1990-1995年就读于首都医科大学临床医学系。2000年考入北京大学医学部，北京大学第一医院泌尿外科暨北京大学泌尿外科研究所硕博连读研究生，2005毕业、获医学博士学位。2005年-2012年于首都医科大学附属北京朝阳医院泌尿外科工作，历任主治医师、副主任医师、主任医师，副教授，硕士生导师。2013年-2014年任首都医科大学附属北京朝阳医院泌尿外科副主任。自2014年至今，于北京大学肿瘤医院泌尿外科工作，受聘博士生导师，教授。2008-2009年于英国Cardiff大学外科学系、威尔士大学医院学习，2009年于德国慕尼黑大学医院学习。2014年参加“将才工程”于美国修斯顿德克萨斯大学MD Anderson肿瘤中心参观学习。从事泌尿外科专业近20年，擅长各种泌尿外科疾病的诊断和治疗。尤善泌尿、男性生殖系统肿瘤以微创为主的综合性治疗，包括腹腔镜、肾镜和软、硬输尿管镜等；并长期关注尿路功能障碍性疾病的诊断和治疗，包括肾积水的综合性、微创治疗，男性尿失禁的综合性诊治等。在全国首先应用分体式输尿管软镜诊断病因不明的血尿，并应用分体式输尿管软镜治疗上尿路低分级肿瘤等疾病。先后参加国家和省部级科研课题15项，主持国家级和省部级科研课题4项，局级课题两项。获得国家教育部科技进步二等奖一项，华夏医学进步奖二等奖一项。目前已于泌尿外科肿瘤、排尿功能障碍、微创治疗等领域发表中文论著40余篇，其中英文论著19篇，参编研究生教材三部，全国规范化教材副主编一部，主译泌尿外科专著一部，参译泌尿外科专著五部，参编泌尿外科专著两部。目前为北京、黑龙江、河北、山东、湖南等多省区特聘评审专家，任泌尿外科时讯编委。社会任职：中国医师协会泌尿外科分会肿瘤学会委员中国医师协会泌尿外科分会青年委员北京肿瘤学会泌尿专业委员会常委北京医学会基础与转化学组委员北京医学会数字泌尿外科学组委员北京医学会罕见病学会泌尿外科专业组委员北京医学会肿瘤分会泌尿外科学组委员中国医疗保健国际交流促进会难治性高血压与周围动脉病学会常委北京健康促进会泌尿外科学会委员中国性科学理事会专家委员会委员中国非公立医疗协会生物技术与细胞应用专业委员会副主任委员中国社区发展协会专家委员会委员中华泌尿外科杂志编委Current Opinion of Urology 中文版编委泌尿外科时讯编委实用医学杂志编委中国肿瘤临床杂志编委发表文章：1、张宁, 周利群, 杜鹏. 各种前列腺癌根治术式的发展特点及并发症. 中华泌尿外科杂志, 2003, 24(4): 282-2842、龚侃, 张宁, 那彦群. 多房囊性肾细胞癌的诊断和治疗分析. 中华医学杂志, 2004, 84(9): 740-742.3、张宁, 龚侃, 果宏峰, 那熙, 吴关, 杨新宇, 辛殿旗, 那彦群. 散发性肾透明细胞癌组织中VHL基因突变与血管内皮生长因子表达及其与微血管形成的关系. 中华医学杂志, 2004, 84(19): 1620-1624.4、龚侃, 张宁, 果宏峰, 张志文, 辛殿旗, 那彦群. 非遗传性肾透明细胞癌中VHL抑癌基因的突变及其意义. 北京大学学报（医学版）, 2004, 36（2）：169-172.5、龚侃, 张宁, 辛钟成, 曾荔, 林桂亭, 那彦群. 阴茎上皮样肉瘤1例报告. 中华男科学, 2004, 10(3):205-207.6、张宁, 李朝争, 龚侃, 李宁忱, 那彦群. 多房囊性肾细胞癌手术治疗的预后特点分析. 中华泌尿外科杂志, 2005, 26(4): 253-255.7、龚侃, 张宁, 那熙, 吴关, 杨新宇, 辛殿旗, 那彦群. 散发性肾透明细胞癌组织中希佩尔-林道基因突变与缺氧诱导因子1α、2α的测定. 中华外科杂志, 2005, 43(6): 390-393.8、刘宁, 龚侃, 张宁, 果宏峰, 那熙, 吴关, 那彦群. 肾细胞癌患者抑癌基因VHL双等位基因失活的测定. 中华泌尿外科杂志, 2005, 43(2): 115-118.9、张宁, 龚侃, 杨勇, 那彦群. 阴囊Paget病的治疗和预后（附23例报告）. 中华男科学杂志, 2006, 12（12）：1102-1104.10、张宁, 龚侃,杨新宇, 辛殿旗, 那彦群. 缺氧诱导因子和血管内皮生长因子在非遗传性肾透明细胞癌中的表达及意义. 中华医学杂志, 2006, 86(22): 1526-1529.11、Gong K, Zhang N(共同第一), Zhang Z, Na Y. Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma. Cancer Biol Ther, 2006, 5(6):582-5.12、张宁, 龚侃, 周利群, 杨勇, 那彦群. 双侧散发性肾癌的外科治疗与预后观察. 中华外科杂志, 2007, 45(2): 121-123.13、杨勇, 严秋哲, 张宁, 牛亦农, 杜鹏. 乙状结肠膀胱扩大术治疗神经原性低顺应性膀胱的疗效观察. 中华泌尿外科杂志, 2007, 28（5）：294-297.14、张宁, 龚侃, 果宏峰, 杨勇, 那彦群. Von Hipple-Lindau基因突变与散发性肾透明细胞癌患者预后的关系. 中华泌尿外科杂志, 2008, 29(11): 740-743.15、Gong K, Zhang N（共同第一）, He Z, Zhou L, Lin G, Na Y. Multilocular cystic renal cell carcinoma: an experience of clinical management for 31 cases. J Cancer Res Clin Oncol, 2008, 134(4):433-437.16、张小东, 尹航, 张宁, 张勇, 杨勇. Studer回肠膀胱的远期排尿功能和并发症的临床研究. 中华泌尿外科杂志, 2008, 46(20): 1536-1538.17、张宁, 张鹏, 王飚, 张小东, 杨勇. 药物联合治疗膀胱疼痛综合征/间质性膀胱炎的疗效及影响因素. 中华泌尿外科杂志, 2009, 30(7): 465-468.18、张宁. 培养生物医学研究生撰写文章的思路. 中国医疗器械信息2010, 16(3): 73-75.19、吴栗洋, 程浩, 邓小虎, 善辉, 王伟, 杨勇, 张小东, 张宁（通讯作者）. 血管内皮生长抑制因子在散发性肾透明细胞癌中的表达及意义. 中华医学杂志, 2013, 93（10）：741-745.20、Zhang N, Sanders AJ, Ye L, Kynaston HG, Jiang WG. Vascular endothelial growth inhibitor, expression in human prostate cancer tissue and the impact on adhesion and migration of prostate cancer cells in vitro. Int J Oncol, 2009, 35(6):1473-1480.21、Zhang N, Sanders AJ, Ye L, Jiang WG. Vascular endothelial growth inhibitor in human cancer (Review). Int J Mol Med, 2009, 24(1):3-8.22、Zhang N, Sanders AJ, Ye L, Kynaston HG, Jiang WG. Expression of vascular endothelial growth inhibitor (VEGI) in human urothelial cancer of the bladder and its effects on the adhesion and migration of bladder cancer cells in vitro. Anticancer Res, 2010, 30(1):87-95.23、Zhang N, Gong K, Zhang X, Yang Y, Na Y. Extramammary Pagets disease of scrotum--report of 25 cases and literature review. Urol Oncol, 2010, 28(1): 28-33.24、Gong K, Zhang N（共同第一）, Zhang K, Na Y. The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma. Int J Mol Med, 2010, 26(6):907-912.25、Ning Zhang, Peng Zhang, Xiaodong Zhang, Yong Yang. The efficacy of resiniferatoxin in prevention of catheter related bladder discomfort in patients after TURP - A pilot, randomized, open study. Transl Androl Urol, 2012, 1(1):14-18.26、Wu P, Zhang N（共同第一）, Wang X, Zhang C, Li T, Ning X, Gong K. The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells. PLoS One, 2012;7(9):e45122.27、Chen S, Zhang HY, Zhang N, Li WH, Shan H, Liu K, Yang Y. Treatment for chronic ischaemia-induced bladder detrusor dysfunction using bone marrow mesenchymal stem cells: an experimental study. Int J Mol Med, 2012, 29(3):416-422.28、Wu P, Zhang N（共同第一）, Wang X, Ning X, Li T, Bu D, Gong K. Family history of von Hippel-Lindau disease was uncommon in Chinese patients: suggesting the higher frequency of de novo mutations in VHL gene in these patients. J Hum Genet, 2012, 57(4):238-243.29、Zhang N, Wu P, Shayiremu D, Wu L, Shan H, Ye L, Zhao X, Cai J, Jiang WG, Gong K, Yang Y. Suppression of renal cell carcinoma growth in vivo by forced expression of vascular endothelial growth inhibitor. Int J Oncol, 2013, 42(5):1664-1673.30、Zhang N, Wu P, Wu L, Shayiremu D, Shan H, Ye L, Jiang WG, Gong K, Yang Y. The differential expression of vascular endothelial growth inhibitor isoforms, VEGI251, VEGI174 and VEGI192 in human clear-cell renal cell carcinoma. Cancer Genomics Proteomics, 2013, 10(1):47-53.31、Wang M, Zhang N, Wang W, Wang B, Xu Z, Yang Y. Expression and function of vascular endothelial growth inhibitor in aged porcine bladder detrusor muscle cells. Biogerontology, 2013, 14(5):543-556.32、Zhang N, Wu P, Shayiremu D, Wu L, Shan H, Ye L, Zhao X, Cai J, Jiang WG, Gong K, Yang Y. Suppression of renal cell carcinoma growth in vivo by forced expression of vascular endothelial growth inhibitor. Int J Oncol, 2013, 42(5):1664-73.33、Zhang N, Wu P, Wu L, Shayiremu D, Shan H, Ye L, Jiang WG, Gong K, Yang Y. The differential expression of vascular endothelial growth inhibitor isoforms, VEGI251, VEGI174 and VEGI192 in human clear-cell renal cell carcinoma. Cancer Genomics Proteomics, 2013, 10(1):47-53.34、Zhang N, Ye L, Wu L, Deng X, Yang Y, Jiang WG. Expression of bone morphogenetic protein-10 (BMP10) in human urothelial cancer of the bladder and its effects on the aggressiveness of bladder cancer cells in vitro. Anticancer Res, 2013, 33(5):1917-1925.35、Zhang N, Zhang XD. Controversy of the prostate-specific antigen test era: should prostate cancer be detected and treated in all patients? Chin Med J (Engl), 2013, 126(15):2803-2804.36、Wu L, Li X, Ye L, Shayiremu D, Deng X, Zhang X, Jiang W, Yang Y, Gong K, Zhang N（通讯作者）. Vascular endothelial growth inhibitor 174 is a negative regulator of aggressiveness and microvascular density in human clear cell renal cell carcinoma. Anticancer Res, 2014, 34(2):715-22.37、Zhang P, Yang Y, Wu ZJ, Zhang N, Zhang CH, Zhang XD. Long-term follow-up of sigmoid bladder augmentation for low-compliance neurogenic bladder. Urology, 2014, 84(3): 697-701.38、Zhang P, Wu ZJ, Xu L, Yang Y, Zhang N, Zhang XD. Bladder neck incision for female bladder neck obstruction: long-term outcomes. Urology, 2014, 83(4):762-6.39、张宁. 泌尿内镜检查教学中的素质教育与健康性认知教育. 中国性科学, 2014, 23(1): 17-19.40、丁文京, 张宁（通讯作者）. 无针吊带技术在治疗女性压力性尿失禁的临床应用研究. 中国性科学, 2014, 23(1):28-3041、洪保安, 张小东, 邢念增, 张宁（通讯作者）. 微波消融治疗肾癌的研究进展. 临床泌尿外科杂志, 2014, 29(5):448-451.42、Chen S, Huang Q, Liu J, Xing J, Zhang N, Liu Y, Wang Z, Li Q. A targeted IL-15 fusion protein with potent anti-tumor activity. Cancer Biol Ther. 2015 Sep 2;16(9):1415-2143、Li L, He P, Zhou C, Jing L, Dong B, Chen S, Zhang N, Liu Y, Miao J, Wang Z, Li Q. A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing. J Immunother. 2015 Nov-Dec;38(9):350-6.44、Baoan Hong, Xin Du, Yuan Zhao, Guowei Chen, Xiaodong Zhang, Ning Zhang* & Yong Yang*. Characteristics of laparoscopic microwave ablation with renal tissue: Experimental in vivo study using a porcine model. Int J Hyperthermia, 2015 Dec;31(8):930-6.45、Qiang Huang, Changhua Zhou, Xiao Chen, Bing Dong, Siqi Chen, Ning Zhang, Yawei Liu, Anrong Li, Meicun Yao, Ji Miao, Qing Li*, Zhong Wang*. Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib. PLoS One. 2015;10(10):e0141395. doi: 10.137146、Ning Zhang, Baoan Hong, Changhua Zhou, Xin Du, Siqi Chen, Xiaohu Deng, Shayiremu Duoerkun, Qing Li, Yong Yang, and Kan Gong. Cobalt Chloride-induced Hypoxia Induces Epithelial-mesenchymal Transition in Renal Carcinoma Cell Lines. Ann Clin Lab Sci. 2017 Jan; 47(1):40-46.47、Baoan Hong, Yong Yang, Sheng Guo, Shayiremu Duoerkun, Xiaohu Deng, Dawei Chen, Shijun Yu, Wubin Qian, Qixiang Li, Qing Li, Kan Gong and Ning Zhang. Intra-tumour molecular heterogeneity of clear cell renal cell carcinoma reveals the diversity of the response to targeted therapies using patient-derived xenograft models. . Oncotarget, 2017, 25;8 (30): 49839-5048、Ning Zhang, Baoan Hong, Wenyong Lian, Changhua Zhou, Siqi Chen, Xin Du, Xiaohu Deng, Shayiremu Duoerkun, Qing Li, Yong Yang, and Kan Gong. Vascular endothelial growth inhibitor 174 and its functional domains inhibit epithelial-mesenchymal transition in renal cell carcinoma cells in vitro.IJMM, 2017, Aug;40(2):569-575.49、Zhao Q, Kun D, Hong B, Deng X, Guo S, Tang X, Yang Y, Gong K, Li Q, Ye L, Jiang WG, Zhang N. Identification of Novel Proteins Interacting with Vascular Endothelial Growth Inhibitor 174 in Renal Cell Carcinoma. Anticancer Res, 2017, 37(8):4379-4388.50、Zhao Q, Deng X, Hong B, Wang F, Tang X, Yang Y, Gong K, Ye L, Jiang WG, Zhang N. Protein of Vascular Endothelial Growth Inhibitor 174 Inhibits Epithelial-Mesenchymal Transition in Renal Cell Carcinoma In Vivo. Anticancer Res, 2017, 37(8):4269-4275.51、赵强，多尔坤，杨勇，杜鹏，曹煜东，王硕，刘佳，汤星星，纪永鹏，张宁. 巨大肾血管平滑肌脂肪瘤行保留肾单位的适应证和手术经验. 中华泌尿外科杂志, 2018,39(5) : 347-350.52、赵强，杨勇，李莉，杜鹏，王硕，汤星星，安超，纪永鹏，张宁. 局部治疗对激素敏感性转移性前列腺癌预后影响的Meta分析. 中华泌尿外科杂志, 2017，38(10) : 791-796.53、Zhao Q1,Liu T, Hong B, Wang F, Zhou C, Du X, Chen S, Deng X, Duoerkun S, Li Q, Yang Y, Gong K, Zhang N. Vascular Endothelial Growth Inhibitor, a Cytokine of the Tumor Necrosis Factor Family, is Associated With Epithelial-Mesenchymal Transition in Renal Cell Carcinoma. Appl Immunohistochem Mol Morphol. 2018 Nov/Dec;26(10):727-733.54、Zhao Q1, Hong B2, Liu T3, Ji Y1, Tang X1, Gong K2, Ye L4, Yang Y1, Zhang N1. VEGI174 protein and its functional domain peptides exert antitumour effects on renal cell carcinoma. Int J Oncol, 2019, 54: 390-398.55、Hong B1, Cai L1, Wang J1, Liu S1, Zhou J1, Ma K1, Zhang J1, Zhou B1, Peng X1, Zhang N2, GongK3.Differential Expression of PD-L1 Between Sporadic and VHL-Associated Hereditary Clear-CellRenal Cell Carcinoma and Its Correlation With Clinicopathological Features. Clin Genitourin Cancer. 2018 Nov 13. pii: S1558-7673(18)30272-656、Wang Y, Liu Y, Zhou C, Wang C, Zhang N, Cao D, Li Q, Wang Z. An AKR1C3-specific prodrug with potent anti-tumor activities against T-ALL. Leuk Lymphoma, 2020: 1-9.57、Liu C, Liu T, Zhang Z, Zhang N, Du P, Yang Y, Liu Y, Yu W, Li N, Gorin M A, Rowe S P, Zhu H, Yan K, Yang Z P. PSMA PET/CT and standard plus PET/CT-Ultrasound fusion targeted prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsies. J Nucl Med, 2020.58、Shan H, Zhang E W, Zhang P, Zhang X D, Zhang N, Du P, Yang Y. Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis - significance in the responsiveness to antihistamine treatment and disease symptoms. BMC Urol, 2019, 19(1): 115.59、Hong B, Ma K, Zhou J, Zhang J, Wang J, Liu S, Zhang Z, Cai L, Zhang N, Gong K. Frequent Mutations of VHL Gene and the Clinical Phenotypes in the Largest Chinese Cohort With Von Hippel-Lindau Disease. Front Genet, 2019, 10: 867.60、Hong B, Zhang Z, Zhou J, Ma K, Zhang J, Cai L, Zhang N, Gong K. Distinctive clinicopathological features of Von Hippel-Lindau-associated hereditary renal cell carcinoma: A single-institution study. Oncol Lett, 2019, 17(5): 4600-4606.61、Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, Li L, Cai L, Zhang N, Zhang Z, Gong K. TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. Int J Biol Sci, 2019, 15(3): 587-597.62、Hong B, Cai L, Wang J, Liu S, Zhou J, Ma K, Zhang J, Zhou B, Peng X, Zhang N, Gong K. Differential Expression of PD-L1 Between Sporadic and VHL-Associated Hereditary Clear-Cell Renal Cell Carcinoma and Its Correlation With Clinicopathological Features. Clin Genitourin Cancer, 2019, 17(2): 97-104.63、Liu C, Liu T, Zhang N, Liu Y, Li N, Du P, Yang Y, Liu M, Gong K, Yang X, Zhu H, Yan K, Yang Z. (68)Ga-PSMA-617 PET/CT: a promising new technique for predicting risk stratification and metastatic risk of prostate cancer patients. Eur J Nucl Med Mol Imaging, 2018, 45(11): 1852-1861.64、赵强，刘辰，刘佳，汤星星，纪永鹏，曹煜东，洪保安，刘特立，杨志，杜鹏，杨勇，张宁. 68Ga-PSMA PET-CT检查中SUVmax与前列腺癌患者临床病理特点的相关性分析[J]. 中华泌尿外科杂志,2020,41(1):13-18.65、杜鑫，洪保安，赵强，纪永鹏，杨勇，张宁. 肾癌循环肿瘤细胞检测及临床应用的研究进展[J]. 中华泌尿外科杂志,2020,41(2):153-156.66、刘佳，曹煜东，汤星星，王硕，杨勇，张宁，杜鹏. 检测循环肿瘤细胞对预测尿路上皮癌淋巴结转移的价值[J]. 中华泌尿外科杂志,2019,40(12):885-888.67、刘辰，刘特立，杨志，张宁，杜鹏，杨勇，刘毅强，王静，严昆，杨兴，朱华，李囡. 68Ga-PSMA-617PET/CT对高危前列腺癌的预测价值[J]. 中华核医学与分子影像杂志,2019,39(2):77-80.68、刘畅，张宁. 从VEGF和sVEGFR2探究分子靶向药物舒尼替尼治疗转移性肾癌的机制[J]. 现代泌尿外科杂志,2019,24(4):309-313.69、洪保安，王江宜，刘圣杰，张九丰，周靖程，马开访，张宁，龚侃. 双侧肾癌相关的分子学研究进展[J]. 中华医学杂志,2018,98(8):638-640.70、中国von Hipple-lindau病诊治专家共识，编委论著及译著参编泌尿外科专著泌尿外科疑难病例精选，人民卫生出版社， ISBN： 978-7-117-13608-2/R?13609下尿路修复重建手术学，人民卫生出版社， ISBN：9787117129282主译泌尿外科专著癌症的早期诊断和治疗-前列腺癌，人民卫生出版社， ISBN：9787117140263参译泌尿外科专著肾移植手册，人民卫生出版社，ISBN：7117075147牛津临床泌尿外科手册，人民卫生出版社， ISBN：9787117075152女性泌尿外科学、泌尿妇科学及排尿功能障碍，人民卫生出版社， ISBN：9787117092203坎贝尔泌尿外科学（第九版），北京大学医学出版社，ISBN：7-81116-457-2Smith腔内泌尿外科学(第二版)，人民卫生出版社，ISBN： 978-7-117-14319-6/R?14320
