简介
王琛，男，中共党员，上海交通大学医学院附属第九人民医院整复外科博士、主任医师、硕士生导师。主要工作涉及鼻整形、腹壁整形、瘢痕整复以及脂肪干细胞治疗等领域。现任中国整形美容协会抗衰老分会青年委员、中华医学会整形外科分会干细胞转化应用学组委员、上海市医学会医学美学与美容青年委员会副主任委员、中整协瘢痕医学分会青年委员，教育部学位中心评审专家，国家自然科学基金评审专家。入选交大医学院优秀青年教师和九院优秀青年骨干，主持省部级课题8项，参与“973”、“863”计划等多个项目的研究，累及发表学术论文30余篇，其中SCI论文22篇（第一/通讯作者），参编专著3部。科研成果：主要发表文章：1. Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells, Biomaterials, 2010,31(4):621-630.2. Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L. Differentiation of adipose derived stem cells into contractile smooth muscle cells induced by TGF-β1 and BMP4, Tissue Eng Part A, 2010,16(4):1201-1213.3. Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage derived morphogenetic protein1, Tissue Eng Part A,2010,16(5):1633-1643.4. Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells, Tissue Eng Part A, 2013, 19(3-4):415-425.5. Wang X,?Qian Y,?Jin R,?Wo Y,?Chen J,?Wang C,?Wang D. Effects?of?TRAP-1-like?protein?(TLP)?gene?on?collagen?synthesis?induced?by?TGF-β/Smad?signaling?in?humandermal?fibroblasts, PLoS One,2013,8(2):e55899.6. Gu H, Xiong Z, Xu J, Li G, Wang C. Clinical and anatomical study of the distally based lesser saphenous veno-lateral sural neurocutaneous flap for lower extremity coverage, J Orthop Sci, 2013,18(5):740-748. (corresponding author)7. Gong L, Wang C, Sun Q, Li G, Wang D. Effects of human adipose derived stem cells on the viability of rabbit random pattern flaps, Cytotherapy, 2014,16(4):496-507. (co-author)8. Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L. Proteomic Analysis Profile of Engineered Articular Cartilage with Chondrogenic Differentiated Adipose Tissue-Derived Stem Cells Loaded Polyglycolic Acid Mesh for Weight-Bearing Area Defect Repair,Tissue Eng Part A, 2014,20(3-4):575-87.9. Gu H, Xiong Z, Yin X, Li B, Mei N, Li G, Wang C. Bone regeneration in a rabbit ulna defect model: use of allogeneic adipose-derived stem cells with low immunogenicity, Cell Tissue Res,2014,358(2):453-64. (corresponding author)10. Wang C, Xiong Z, Xu J, Zhang L, Huang H, Li G. The distally based lateral sural neuro-lesser saphenous veno-fasciocutaneous flap: anatomical basis and clinical applications, J Orthop Traumatol, 2014,15(3):215-23.11. Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L. Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression. PLoS One. 2014;9(6):e100818.12.Wang X,?Chu J,?Wen C,?Fu S,?Qian Y,?Wo Y,?Wang C,?Wang D. Functional?characterization?of?TRAP1-like?protein?involved?in?modulating?fibrotic?processes?mediated?by TGF-β/Smad?signaling?in?hypertrophic?scar?fibroblasts. Exp Cell Res.2015;332(2):202-11. (corresponding author)13. Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C, Allogeneic Adipose-derived Stem Cells Regenerate Bone in a Critical-sized Ulna Segmental Defect. Exp Biol Med .?2015 Mar 27. (corresponding author)14． Lv Y, Cao D, Guo F, Qian Y, Wang C, Wang D. Abdominal wall reconstruction using a combination of free tensor fasciae lata and anterolateral thigh myocutaneous flap: a prospective study in 16 patients.Am J Surg.?2015;210(2):365-73. (corresponding author)15. Zhou R, Zhang Q, Zhang Y, Fu S, Wang C.Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Exp Cell Res. 2015 Oct 20. (corresponding author)16. 王琛，徐静，张莉，熊竹友，李光早。指背血管蒂岛状皮瓣应用解剖。 中国临床解剖学杂志。2006;24(5):514-517。17. 王琛，郭芳芳，张昀，等。 应用脂肪干细胞构建小口径组织工程血管平滑肌层的实验研究. 组织工程与重建外科杂志. 2012,8(5):249-25518.熊竹友，方小魁，徐静，张莉，王琛，李光早。同种异体脂肪干细胞复合脱钙骨修复大鼠尺骨缺损。组织工程与重建外科杂志,2013,9(5):245-251.（通信作者）19. 张奇，王琛。microRNA-21调控TGF-β通路促进增生性瘢痕形成的机制研究。组织工程与重建外科杂志,2014,10(6):318-323. （通信作者）20．张奇，王琛。VSD技术临床应用研究现状. 中华医学杂志，2014,11(10):52-56。（通信作者）21. 张奇，王琛。miRNA参与调控皮肤创伤修复的发生发展。医学美学美容，2015,1(1):35-36。（通信作者）承担课题1. 上海市自然科学基金：应用脂肪干细胞构建双层结构的组织工程化血管修复小口径动脉缺损的实验研究（11ZR1420300）2. 国家自然科学基金青年基金：力学刺激诱导miR-100诱导脂肪干细胞向平滑肌细胞分化的作用和机制（810201204）3. 上海高校青年教师科研专项基金：miR-21调控Smad7基因表达在增生性瘢痕形成中的作用及机制（ZZjdyx12100）4. 上海交大医学院优秀青年教师人才计划：miR-31/FIH轴调控HIF-1α通路促进增生性瘢痕发展的机制研究5. 第五届“九院优青培养计划”： miR-21调控TGF-β通路在增生性疤痕形成中的作用及机制
